nphPower: Sample Size Calculation under Non-Proportional Hazards
Performs combination tests and sample size calculation for
fixed design with survival endpoints using combination tests under either
proportional hazards or non-proportional hazards. The combination tests
include maximum weighted log-rank test and projection test. The sample
size calculation procedure is very flexible, allowing for user-defined
hazard ratio function and considering various trial conditions like
staggered entry, drop-out etc. Trial simulation function is also provided
to facilitate the empirical power calculation. The references for
projection test and maximum weighted logrank test include Brendel et al. (2014)
<doi:10.1111/sjos.12059> and Cheng and He (2021) <arXiv:2110.03833>. The
references for sample size calculation under proportional hazard include
Schoenfeld (1981) <doi:10.1093/biomet/68.1.316> and Freedman (1982) <doi:10.1002/sim.4780010204>.
The references for calculation under non-proportional hazards include
Lakatos (1988) <doi:10.2307/2531910> and Cheng and He (2021) (under review).
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